一、課題組簡介

張志國教授實驗室（https://zgzhanglab-columbia.com）位于美國哥倫比亞大學醫學院腫瘤遺傳中心（Institute for Cancer Genetics），主要研究方向為DNA復制時表觀遺傳信息傳遞的分子機制以及腫瘤表觀遺傳調控。張志國教授課題組自2003年組建以來，發表論文百余篇，其中包括Science，Cell，Nature，Molecular Cell，Cancer Discovery等眾多國際知名專業期刊雜志。相關研究成果在表觀遺傳調控領域具有很高的影響力。張志國教授課題組自組建以來已培養出獨立PI若干名，就職于北京大學，浙江大學，中國科學院等知名高校，具有很好的發展潛力。課題組目前經費充足，急需對細胞表觀遺傳學和腫瘤表觀遺傳學感興趣的優秀青年加入。

哥倫比亞大學醫學院位于紐約曼哈頓島，風景優美，交通便利，毗鄰多所著名研究機構，包括洛克菲勒研究所，斯隆-凱特琳癌癥中心，康奈爾醫學院等，具有優越的學術交流機會以及未來就業機會。

課題組主要研究方向：

1.DNA復制過程中組蛋白裝配的調節過程。

2.組蛋白裝配與轉座子沉默的機制研究。

3.膠質母細胞瘤中組蛋白突變誘導腫瘤發生的機制。

4.CRISPR/Cas9篩選膠質母細胞瘤的藥物治療靶點。

5.通過血漿cfDNA進行的早期癌癥診斷。

二、應聘條件

已獲得或將獲得生物或醫學相關博士學位，能獨立開展相關科研課題，具有分子生物學，腫瘤生物學，蛋白純化，結構生物學，基因組與生物信息學相關背景的同學優先。

三、應聘方式

有意者請將個人簡歷以及三位推薦人聯系方式發送至郵箱：zz2401@cumc.columbia.edu，郵件標題注明：應聘崗位+畢業學校+本人姓名+高校人才網【快捷投遞：點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】

Postdoctoral fellow positions are available to study mechanisms of epigenetic inheritance and cancer epigenetics at Columbia University Irving Medical Center.

The first long-term goal of our laboratory is to determine how chromatin states are inherited during S phase of the cell cycle and how this process when going awry, leads to genome instability. Specifically, we focus on elucidating nucleosome assembly pathways are regulated using a variety of systems including yeast, mouse embryonic stem cells and human cells. We have made major contributions to this field. Our second long-term goal is to determine how epigenetic changes drive tumorigenesis and drug resistance. My laboratory is one of the first laboratories that discovered how onco-histone mutations, H3K27M (found in diffuse intrinsic midline glioma (DMG)) and H3.3K36M (found in chondroblastoma and head and neck cancer), reprogram cancer epigenomes and drive tumorigenesis. Currently, we aimed at identification and characterization of epigenetic vulnerability of H3K27M cells aimed at identifying drug targets for this deadly disease.

Candidates with a strong background in molecular biology, cancer biology, protein purification and structural biology are strongly encouraged to apply. Detailed information about our laboratory and Research Projects can be found online:

https://zgzhanglab-columbia.com

Interested candidates email their CV and the names of three references to zz2401@cumc.columbia.edu.

部分發表論文列表：

1. Xu X, Duan S, Hua X, Li Z, He R, and Zhang Z. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions (2022). Nature Communications, 13: 2514.

2. Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K and Zhang Z. Epigenome programing by H3.3K27M mutation creates a dependence of pediatric glioma on SMARCA4 (2022). Cancer Discovery, 12:2906-2929.

3. Yu, C., Gan, H., Serra-Cardona, A., Zhang, L., Gan, S., Sharma, S., Johansson, E., Chabes, A., Xu, R.M., Zhang, Z. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands (2018). Science, 361:1386-1389.

3. Zhang, L., Serra-Cardona, A., Zhou, H., Wang, M., Yang, N., Zhang, Z*. and Xu, R*. Multisite substrate recognition in Asf1-dependent acetylation of histone H3K56 by Rtt109 (2018). Cell 174, 174(4):818-830  

4. Fang D, Gan H, Lee J, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z (2016). The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 352: 1344-1348.