中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
實驗室介紹
王宇濤實驗室現面向國內外招聘博士后與科研助理！實驗室致力于研究感染、炎癥及腫瘤發展的免疫調控機制，重點關注核受體家族在病毒感染、腫瘤免疫及免疫應答性別差異中的關鍵作用，同時結合小分子藥物開發和合成生物學工具，探索并推動新型疾病治療策略的研發與轉化應用。實驗室擁有前沿且具有挑戰性的研究方向、完善的科研平臺、充足的經費支持與友好開放的科研氛圍，重視每一位成員的成長與發展。如果你渴望在一個積極向上、合作融洽的團隊中，探索生命科學的前沿問題，收獲專業能力與成長快樂，歡迎加入我們！
王宇濤研究員本科畢業于蘭州大學，博士畢業于北京大學，師從蔣爭凡教授，博士期間研究工作揭示了Caspase家族成員在天然免疫穩態和維持細胞凋亡免疫沉默中的調控作用；之后在哈佛醫學院Christophe Benoist和Diane Mathis實驗室完成博士后訓練，運用體內高通量Rainbow-CRISPR篩選系統研究核受體家族在免疫細胞分化與細胞命運調控中的作用。王宇濤研究員將于2025年6月正式加入首都醫學科學創新中心。
主要研究方向
1.核受體在病毒誘導的代謝重編程和天然免疫應答中的調控機制。
2.核受體在腫瘤進展與抗腫瘤免疫調控中的作用及其治療潛力。
3.核受體介導免疫應答性別差異的分子機制研究。
4.基于合成生物學的轉錄因子活性檢測和精準治療策略開發。
主要成果與貢獻
1. 建立體內高通量“Rainbow-CRISPR”篩選系統，系統解析核受體家族成員在免疫細胞分化和穩態維持中的作用，揭示視黃酸受體通過轉錄調控和炎癥小體活化雙重機制調控GATA6?腹腔巨噬細胞命運（Immunity，2024，一作）。
2. 揭示TRAF6介導的ASK1 Lys6-連接的多聚泛素化修飾在肝臟炎癥和纖維化的關鍵作用（Hepatology，2019，一作）；發現NLK激酶是抑制肝糖異生的關鍵分子，揭示血糖穩態調控的新機制（Cell Metabolism，2021，并列一作）。
3. 闡明Caspase家族成員在抗病毒天然免疫穩態和維持細胞凋亡免疫沉默中的調控作用（Immunity，2017，一作；Molecular Cell，2019，并列一作）。
代表性文章
Wang et al., 2024, Immunity, PMID: 39571575
Ji, Wang et al., 2021, Cell Metabolism, PMID: 33951476
Wang et al., 2020, Hepatology, PMID: 31222801
Ning, Wang et al., 2019, Molecular Cell, PMID: 30878284
Wang et al., 2017, Immunity, PMID: 28314590
免疫方向博士后
一、崗位職責
1.參與課題組科研工作，獨立承擔相應科研課題；
2.協助課題組長指導研究生實驗；撰寫基金和申報課題等相關工作。
二、崗位要求
1.近三年已經或即將獲得免疫學、腫瘤學、細胞分子生物學或其他生物醫學領域博士學位，具有代謝調控或者抗病毒天然免疫信號轉導研究背景者優先；
2.具有扎實的分子和細胞生物學背景，如細胞培養、基因編輯、流式分析等技術，在小鼠模型實驗或者生物信息學（多組學分析）方面具有較強的專業技能優先；
3.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文，能夠獨立開展研究工作，具備高度的科研熱情和嚴謹的科研態度；
4.責任心強，具有良好的團隊合作精神，具備基本的英文溝通與學術寫作能力。
生物信息學方向博士后
一、崗位職責
1.參與課題組科研工作，獨立或合作承擔相應科研課題；
2.協助課題組長指導研究生,撰寫基金和申報課題等相關工作。
二、崗位要求
1.近三年已經或即將獲得生物信息學、計算生物或系統生物學等相關專業博士學位,具有表觀遺傳組學（ChIP-Seq,ATAC-Seq,RNA-seq等）及單細胞測序數據分析，開發復雜生物信息算法或流程的經驗者優先；
2.熟練掌握C++、python或R語言，熟悉Linux操作系統，能夠高效處理與分析大規模生物數據；
3.工作認真負責，有良好的溝通能力和團隊合作精神；
4.有良好的英語表達和論文寫作能力。
科研助理
一、崗位職責
1.參與課題組科研工作，承擔相應科研任務；
2.負責實驗室經費管理，耗材訂購等工作。
二、崗位要求
1.具有免疫學、腫瘤學、細胞分子生物學等相關專業的本科及以上學位；
2.掌握常規分子克隆、細胞培養的操作原理，有實驗室研究工作經歷優先；
3.有責任心和團隊精神，熱愛創新與挑戰；
4.具備基本的英文溝通、寫作能力。
福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
申請方法
請將簡歷、個人陳述（1頁）、2名推薦人的基本信息和聯系方式、工作總結與研究興趣（1-2頁，僅限博士后）以及其他申請人認為必要的材料，合并為PDF文件發送至wangyutao@cimrbj.ac.cn，并在郵件主題中注明：“應聘博士后/科研助理+本人姓名+所在學校/單位”，初審通過的申請者將會盡快安排面試，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】。
聯系人：王老師
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
The Chinese Institutes
for Medical Research (CIMR) is a newly founded institution dedicated to
fundamental and translational medical research. The CIMR is located at the main
campus of the
Laboratory Introduction
Dr. Wang’s Laboratory at CIMR is now hiring postdoctoral fellows and research assistants! The lab is dedicated to uncovering the regulatory mechanisms underlying infection, inflammation, and tumor progression, with a particular focus on the nuclear receptor (NR) family in viral infections, cancer immunity, and sex-based differences in immune responses. By integrating small-molecule drug development and synthetic biology approaches, we aim to develop and advance innovative therapeutic strategies for human diseases.
Our group pursues cutting-edge and ambitious scientific projects, backed by a well-equipped research platform, robust funding, and a collaborative, inclusive lab environment. We firmly believe that science makes life better, and we actively encourage open communication, curiosity-driven exploration, and continuous personal and professional growth. Our goal is to balance dedicated research with a fulfilling life. If you're passionate about exploring the frontiers of life science in a supportive and collaborative team, and to grow both professionally and personally, we warmly welcome you to join us!
Dr. Wang received his
bachelor’s degree from
Major Research Projects
a. Exploring the functions of nuclear receptors in viral infection-induced metabolic reprogramming and innate immune responses.
b. Dissecting the functions of nuclear receptors in tumor progression and immune regulation.
c. Uncovering the roles of nuclear receptors in sex-based differences in immune responses.
d. Targeting disease-specific transcriptional activity for precision therapy using synthetic biology approaches.
Major Contributions
a. Developed an innovative in vivo Rainbow-CRISPR screening platform and systematically investigated the nuclear receptor family in the differentiation and homeostatic control of 28 immune cell types, revealing that retinoic acid receptors regulate the fate of GATA6+ large peritoneal macrophages via transcriptional control of cell differentiation and inflammasome-mediated control of cell death (Immunity, 2024, first author).
b. Discovered a novel TRAF6-mediated Lys6-linked polyubiquitination of ASK1, which plays a pivotal role in of hepatic inflammation and fibrosis (Hepatology, 2019，first author); and identified NLK as a key suppressor of hepatic glucose production by inhibiting gluconeogenesis (Cell Metabolism, 2021, first author).
c. Identified the critical roles of the Caspase family in maintaining antiviral innate immune homeostasis and preserving immunological silence during apoptosis (Immunity, 2017, first author; Molecular Cell, 2019, co-first author).
Representative Publications
Wang et al., 2024, Immunity, PMID: 39571575
Ji, Wang et al., 2021, Cell Metabolism, PMID: 33951476
Wang et al., 2020, Hepatology, PMID: 31222801
Ning, Wang et al., 2019, Molecular Cell, PMID: 30878284
Wang et al., 2017, Immunity, PMID: 28314590
Open Positions
Postdoctoral Research Fellow
– Immunology
Main Responsibilities
a. Lead independent research projects and collaborate with lab members.
b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.
Qualifications
a. Ph.D. in immunology, oncology, molecular / cellular biology, or a related biomedical field (obtained within the past three years or expected soon).
b. Solid background in molecular and cellular biology, including cell culture, gene editing, and flow cytometry. Experience with mouse immune-mediated disease models or bioinformatics (e.g., multi-omics analysis) is preferred.
c. Proven track record as first author in high-impact journals or manuscripts under revision; capable of conducting independent research with strong scientific enthusiasm and rigor.
d. Strong responsibility, excellent teamwork and communication skills, and proficient in English communication and scientific writing.
Postdoctoral Research Fellow
– Bioinformatics
Main Responsibilities
a. Lead independent research projects and collaborate with other team members.
b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.
Qualifications
a. Ph.D. in bioinformatics, computational biology, systems biology, or a related field (obtained within the past three years or expected soon); experience in epigenomic data analysis (e.g., ChIP-Seq, ATAC-Seq, RNA-Seq), single-cell sequencing, or development of bioinformatics pipelines/algorithms is highly preferred.
b. Proficient in C++, Python, R, and Linux; capable of processing and analyzing large-scale biological datasets.
c. Highly responsible, self-motivated, with excellent communication skills and a collaborative mindset.
d. Proficient in English communication and scientific writing.
Research Assistant
Main Responsibilities
a. Support research projects independently or in collaboration with lab members.
b. Assist with daily lab operations, including the management of supplies and ordering of reagents.
Qualifications
a. Bachelor’s degree or above in immunology, oncology, molecular and cellular biology, or related fields.
b. Prior research experience in molecular biology and cell culture is preferred.
c. Self-motivated researcher with strong sense of responsibility, good communication skills, and teamwork ability.
d. Basic proficiency in English communication and scientific writing.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to wangyutao@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject. Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.
Contact person: Dr. Wang
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來源于網絡，如有變更請以原發布者為準。
來源鏈接：
https://mp.weixin.qq.com/s/92Z
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