一、中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
二、實驗室介紹
冷方偉研究員本科畢業于四川大學吳玉章學院，在中科院生物物理研究所獲得博士學位后加入哈佛醫學院/HHMI Sun Hur實驗室擔任博士后/講師，將于2025年5月加入首都醫學科學創新中心創建獨立實驗室，圍繞蛋白質互作、染色質三維結構及表觀遺傳修飾等方面系統研究調節性T細胞（Treg）的工作機制，并設計靶向關鍵蛋白如FoxP3的小分子，多肽藥物和納米抗體以調控調節性T細胞功能，開發自身免疫疾病和腫瘤治療策略。
實驗室網站：https://www.cimrbj.ac.cn/channel/1896742745033281536.html
三、主要研究方向
1.調節性T細胞在免疫穩態與疾病發生中的機制研究；
2.靶向調節性T細胞功能的藥物開發；
3.探索微衛星DNA的生物學功能及其潛在的臨床相關性。
01主要成果與貢獻
1.揭示了FoxP3兩種二聚化狀態對調節性T細胞功能的影響（Immunity，2022，封面文章）；
2.發現FoxP3識別并橋接TnG微衛星DNA以促進增強子-啟動子環化（Nature，2023）；
3.發現FoxP3通過不同多聚體結構識別多種微衛星DNA以重塑染色質三維結構 （Molecular Cell，2025）。
02代表性文章
Molecular Cell.2025 (In press)
Nature.2023 Dec; 624(7991): 433-441.PMID: 38030726
Immunity.2022 Aug 9; 55(8): 1354-1369.e8.PMID: 35926508
四、崗位信息
01博士后
1）崗位職責
1.獨立開展課題研究項目；
2.協助PI指導研究生, 撰寫論文及基金申請。
2）任職要求
1.具有免疫學、生物信息學、分子生物學、細胞生物學、生物化學或其他生物醫學領域研究背景，即將或已經獲得博士學位（原則上不超過3年）；
2.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文，能夠獨立開展研究工作，具有科研熱情和嚴謹的科研態度；
3.有免疫學、基因組學、生物信息學等研究經驗者優先；
4.精通英語閱讀、寫作和日常溝通，能夠使用英語撰寫論文。
02科研助理
1）崗位職責
1.獨立或協助團隊開展研究工作；
2.管理和維護實驗室日常工作和行政事務。
2）任職要求
1.具有化學、藥學、生物學、基礎醫學等相關專業的本科及以上學位；
2.掌握常規分子克隆、生物化學、細胞培養的操作及原理，有實驗室研究工作經歷優先；
3.有較強的主觀能動性，具備良好的溝通能力和團隊協作能力；
4.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。
五、福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
六、申請方法
請將簡歷、個人陳述（1頁）、2名推薦人的基本信息和聯系方式、工作總結與研究興趣（1-2頁，僅限博士后）以及其他申請人認為必要的材料，合并為PDF文件發送至fangwei.leng@cimrbj.ac.cn，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】，并在郵件主題中注明：“應聘博士后/科研助理+本人姓名+所在學校/單位”，初審通過的申請者將會盡快安排面試。
聯系人：冷老師
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn
Laboratory Introduction
The Leng Laboratory at CIMR investigates the molecular mechanisms by which FoxP3 regulates the gene network of regulatory T cells (Tregs).Our research explores multiple perspectives, including the protein interactome, three-dimensional chromatin architecture, and epigenetic modifications.Our long-term goal is to develop drugs targeting FoxP3 to modulate Treg activity, providing potential therapeutic strategies for both autoimmune diseases and cancer.
Major Research Projects
a.Exploring the molecular mechanisms of FoxP3 in regulating the gene expression in Tregs.
b.Developing small molecules, Peptides and Nanobodies to Modulate FoxP3 Function.
c.Exploring the role of microsatellites in gene regulation and genetic disorders.
Major Contributions
a.Uncovering the critical role of FoxP3 head-to-head dimerization in Treg function (Immunity, 2022).
b.Discovering that FoxP3 recognizes and multimerizes on TnG repeat microsatellites, revealing a novel DNA-bridging mechanism (Nature, 2023).
c.Revealing the role of versatile FoxP3 ensembles in three-dimensional genomic architecture (Molecular Cell, 2025).
Representative Publications
Molecular Cell.2025 (In press)
Nature.2023 Dec; 624(7991): 433-441.PMID: 38030726
Immunity.2022 Aug 9; 55(8): 1354-1369.e8.PMID: 35926508
Open Positions
Postdoctoral Researcher
Main Responsibilities
a.Conducting research projects independently.
b.Assisting PI to mentor graduate students, write grant proposals and manuscripts.
Qualifications
a.Backgrounds in biology or biomedical fields.Either about to obtain a Ph.D.or recently obtained a Ph.D.degree (ideally within the last 3 years).
b.Published or about to publish research papers as the first author in reputable journals in the field.With motivation and ability to independently carry out research projects.
c.Research experience in immunology, Genomics and Bioinformatics is appreciated and favored.
d.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.
Research Assistant
Main Responsibilities
a.Conducting research projects independently or in collaboration with other lab members.
b.Getting involved in lab data analysis and management.
Qualifications
a.A B.S or higher degree in biology, basic medical science and other relevant majors is required.
b.Research experience in molecular biology, biochemistry, cell biology is preferred.
c.Self-motivated researcher with good communication skill and teamwork ability.
d.Proficient in English reading, writing, and daily communication.
Welfare Treatment
a.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c.Support career development, provide relevant professional guidance.
How to apply
Please compile your CV, one-page personal statement, basic information and contact details of two referees and a 1-2 page research summary and interests (for postdoc position only), as well as other materials demonstrating research capabilities into a single PDF file.Send it to fangwei.leng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name + University/Employer” in the email subject.Review of applications will begin on a rolling basis, and qualified applicants will be invited for an interview.
Contact person: Dr.Leng
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來源于網絡，如有變更請以原發布者為準。
來源鏈接：
https://mp.weixin.qq.com/s/FESfAjYveXhYElETO3Frbg
更多最新博士后招收資訊請關注高才博士后微信公眾號（微信號：bshjob）。
