一、中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家及其科研團隊，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
二、實驗室介紹
Hansen實驗室專注于研究興奮性細胞在天然三維狀態下的信號傳導，以便更好地理解人類疾病的分子基礎。通過研究這些分子機制，旨在闡明疾病的發展過程，并開發出預防或減輕疾病影響的治療方法。
三、主要研究課題
1.利用超分辨率成像和空間生物學建立膜介導麻醉的分子基礎。
2.研究膽固醇在驅動炎癥性疾病（包括阿爾茨海默癥和慢性疼痛）中的分子作用。
3.利用新型藥物發現試驗開發非成癮性鎮痛藥（止痛藥）。
4.揭示低閾值時膜介導的機械感覺的分子基礎。
四、主要成果與貢獻
1.在哺乳動物細胞和果蠅中發現了一種膜介導的麻醉作用機制（PNAS, 2020）。
2.建立了調節鉀通道的膜介導機械感覺機制（eLife, 2024; Nature Communications, 2016）。
3.發現星形膠質細胞膽固醇是阿爾茨海默癥中淀粉樣蛋白生成的調節因子（PNAS, 2021）。
4.證明信號脂質可作為離子通道的直接激動劑（BBA, 2016; Nature, 2011）。
五、代表性文章
eLife, 2024, 12: RP89465.DOI: 10.7554/eLife.89465.
Pharmacology & Therapeutics, 2023, 249: 108486.DOI: 10.1016/j.pharmthera.2023.108486.
The Journal of biological chemistry, 2023, 299: 104763.DOI: 10.1016/j.jbc.2023.104763.
PNAS, 2021, 118: e2102191118.DOI: 10.1073/pnas.2102191118.
PNAS, 2020, 117: 13757–13766.DOI: 10.1073/pnas.2004259117.
六、崗位信息
01博士后
1）主要職責
1.獨立開展課題研究項目；
2.協助PI指導研究生，撰寫論文及基金申請。
2）任職要求
1.生物學、生物化學或生物醫學領域背景。獲得博士學位（最近兩年內優先）或即將完成博士學位；
2.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文；
3.有電生理學、超分辨率顯微鏡或冷凍電鏡研究經驗者優先；
4.在分子生物學、蛋白質純化、原代細胞培養和/或小鼠研究方面有豐富的研究經驗；
5.精通英語閱讀、寫作和日常溝通，能夠使用英語撰寫論文。
02實驗室管理員
1）主要職責
1.訂購和管理實驗室耗材和試劑，制備常用緩沖液和溶液；
2.實驗室日常管理及費用核算和報銷；
3.安排實驗室會議和其他例行活動。
2）任職要求
1.本科及以上學歷，生命科學、醫學等相關專業，有實驗室管理工作經驗者優先考慮；
2.具有優秀的溝通能力和團隊合作能力；
3.精通中英文閱讀、寫作和日常溝通；
4.熟悉日常辦公軟件。
七、福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
八、申請方法
請將簡歷、研究興趣或計劃（僅限博士后）、2-3名推薦人的姓名和聯系方式以及其他證明研究能力的材料發送至shansen@cimrbj.ac.cn，并在郵件主題中注明申請人的姓名和具體職位，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】。
聯系人：Scott Hansen
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
The Chinese Institutes
for Medical Research (CIMR) is a newly founded institution dedicated to
fundamental and translational medical research.The CIMR is located at the main
campus of the
Laboratory Introduction
The Hansen Laboratory at CIMR focuses on studying the signaling of excitable cells in their native three-dimensional state to better understand the molecular basis of human disease.By investigating these molecular mechanisms, we aim to elucidate disease progression and develop therapies to prevent or mitigate its impact.
Major Research Projects
1.Establishing the molecular basis for membrane-mediated anesthesia using super-resolution imaging and spatial biology.
2.Investigating the molecular role of cholesterol in driving inflammatory diseases, including Alzheimer’s disease and chronic pain.
3.Developing non-addictive analgesics (pain medications) using novel drug discovery assays.
4.Uncovering the molecular basis of membrane-mediated mechanosensation at low thresholds.
Major Contributions
1.Identified a membrane-mediated mechanism of anesthetic action in mammalian cells and in fruit fly (PNAS, 2020)
2.Established a membrane-mediated mechanism of mechanosensation regulating a potassium channel (eLife, 2024; Nature Communications, 2016)
3.Identified astrocyte cholesterol as a regulator of amyloid production in Alzheimer’s Disease (PNAS, 2021)
4.Demonstrated that signaling lipids act as direct agonists of ion channels (BBA, 2016; Nature, 2011)
Representative Publications
eLife, 2024, 12: RP89465.DOI: 10.7554/eLife.89465.
Pharmacology & Therapeutics, 2023, 249: 108486.DOI: 10.1016/j.pharmthera.2023.108486.
The Journal of biological chemistry, 2023, 299: 104763.DOI: 10.1016/j.jbc.2023.104763.
PNAS, 2021, 118: e2102191118.DOI: 10.1073/pnas.2102191118.
PNAS, 2020, 117: 13757–13766.DOI: 10.1073/pnas.2004259117.
Open Positions
Postdoctoral Researcher
Main Responsibilities
a.Conduct research projects independently.
b.Assist PI to mentor graduate students, write grant proposals and manuscripts.
Qualifications
a.Backgrounds in biology, biochemistry, or biomedical fields.A recent Ph.D.degree (ideally within the last 2 years) or about to complete a PhD.
b.Published or about to publish a first author research paper in a reputable journal.
c.Research experience in electrophysiology, super-resolution microscopy, or cryoEM is appreciated and favored.
d.Strong research experience in molecular biology, protein purification, primary cell culture, and/or mouse studies.
e.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.
Laboratory Manager
Main Responsibilities
a.Order and manage laboratory consumables and reagents and prepare commonly used buffers and solutions.
b.Laboratory daily management and expense accounting and reimbursement.
c.Arrange lab meetings and other routine activities.
Qualifications
a.Have a bachelor's degree or above degree in life science- or medicine-related majors.
b.Have excellent communication skills and teamwork skills.
c.Proficient in English and Chinese reading, writing, and daily communication.
d.Familiar with daily office software.
e.Priority will be given to applicants with laboratory management experience.
Welfare Treatment
a.Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b.Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c.Support career development and provide relevant professional guidance.
How to apply
Please send a resume, research interest or plan (for postdoc position only), the names and contacts of 2-3 referees and other materials demonstrating research capabilities to shansen@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.
Contact person: Scott Hansen
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來源于網絡，如有變更請以原發布者為準。
來源鏈接：
https://mp.weixin.qq.com/s/eOTc_VJ6TLmaj_LX2zkklg
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