一、中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
二、實驗室介紹
首都醫學科學創新中心腫瘤研究所張昱實驗室長期招聘博士后、副研究員和科研助理以開展腫瘤免疫，神經免疫和自身免疫病的基礎研究和臨床轉化。本實驗室長期開發并使用功能基因組篩選、多組學高通量測序技術和生物信息分析等方法，結合體內、體外小鼠和人類腫瘤模型，研究腫瘤免疫中關鍵分子的調控機制，研發腫瘤免疫治療的新方法，并將研究成果進行臨床轉化。包括但不限于以下研究方向：
1.腫瘤免疫中新機制和免疫檢查點的鑒定和靶向方法：腫瘤的免疫治療是目前治療腫瘤最有效的策略之一。然而，這些免疫療法只在某些腫瘤類型和某些患者中表現出顯著療效，其中的機制目前尚不清楚。本實驗室通過將體外和體內的全基因組及定制的CRISPR/Cas9篩選相結合，旨在系統地鑒定出可調控腫瘤免疫治療效果的新基因和相關通路。
2.腫瘤免疫中B細胞的功能和調控：T淋巴細胞所介導的適應性細胞免疫在腫瘤免疫應答中具有重要作用，但B淋巴細胞在腫瘤的發生、發展及治療中所起到的作用是近年來才逐漸被關注到的，且大多都存在爭議。有趣的是，近來的研究表明，在患者接受免疫治療時，腫瘤內的B細胞和三級淋巴結構（TLSs）可能與更好的預后相關，但其中的細胞和分子機制目前仍不清楚。本實驗室正致力于將人類TLSs的多組學分析與小鼠腫瘤模型相結合，以剖析B淋巴細胞在腫瘤免疫中的具體作用。
3.利用細胞工程和基因組編輯治療人類疾病：隨著對人類疾病中分子和細胞機制的深入了解，靶向特定致病細胞或其前體細胞的策略已逐漸發展為新一代治療手段。其中，細胞療法（如嵌合抗原受體T細胞（CAR-T）、CAR-NK、CAR-Macrophage等）對某些人類腫瘤展現出了驚人的療效。有趣的是，近年來這類靶向致病細胞的療法已擴展到其他非腫瘤疾病領域，如心臟纖維化和衰老相關疾病。本實驗室正在開發新一代的細胞治療策略用于治療人類疾病。
三、代表性論文
1.組蛋白脫乙酰化酶6的功能（EMBO J，2003；G & D，2005；JBC，2006；MCB，2008）
2.染色體轉位的機制（Cell，2011；Cell，2012；Cell，2013；PNAS，2016）
3.Cas9的脫靶和靶向機制（Cell Research，2014）
4.利用Cas9進行基因組標記（Genome Biology，2018a；Genome Biology，2018b；JMCB，2019）
5.利用單細胞測序研究免疫細胞在疾病中的變化和功能（Circulation，2020；Nature Communications，2021）
四、崗位信息
01博士后/副研究員
1）崗位職責
1.獨立開展和參與實驗室課題研究工作;
2.協助PI指導研究生實驗；撰寫基金和申報課題等相關工作。
2）任職要求
1.已經或即將獲得免疫學、腫瘤學、細胞分子生物學、生物信息學或其他生物醫學領域博士學位，具有相關領域研究背景，副研究員需要有博士后研究經歷；
2.具備獨立開展科研工作和指導研究生能力，具有科研熱情和嚴謹的科研態度；
3.有扎實的免疫學，生物信息學，腫瘤免疫或自身免疫模型實驗背景者優先考慮；
4.具備熟練的英文交流和讀寫能力，可以獨立撰寫英文論文。
02科研助理
1）崗位職責
1.參與課題組科研工作，承擔相應科研任務；
2.維護實驗室日常工作及運行。
2）任職要求
1.具有免疫學、腫瘤學、細胞分子生物學等相關專業的本科及以上學位；
2.掌握常規分子克隆、細胞培養或動物實驗的操作原理，有實驗室研究工作經歷優先；
3.有責任心和團隊精神，熱愛創新與挑戰。
五、福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
六、申請方法
請將簡歷、個人陳述、至少2名推薦人的基本信息或聯系方式、工作總結與研究興趣（1-2頁，僅限副研究員/博士后），合并為PDF文件發送至zhangyu@cimrbj.ac.cn，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】，并在郵件主題中注明：“應聘副研究員/博士后/科研助理+本人姓名”，初審通過的申請者將會盡快安排面試。
聯系人：張老師
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn
Laboratory Introduction
The laboratory of Yu Zhang at the Chinese Institutes for Medical Research (CIMR) works on the identification of key molecules in tumor immunology, by genome-wide functional screenings, multi-omics, high-throughput sequencing technology, and bioinformatic analysis. Our ultimate goals are developing new strategies for tumor immunotherapy, and translating basic research into clinical trials.
Open Positions
Research Scientists &
Postdoctoral Research Fellow
Biochemistry, Cell and Molecular Biology, Immunology, Cancer Biology, and other biomedical sciences
Main Responsibilities
a. Lead independent research projects and collaborate with lab members.
b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.
Qualifications
a. Ph.D. in immunology, oncology, molecular / cellular biology, or a related biomedical field (obtained within the past three years or expected soon).
b. Solid background in molecular and cellular biology, including cell culture, gene editing, and flow cytometry. Experience with mouse immune-mediated disease models or bioinformatics (e.g., multi-omics analysis) is preferred.
c. Proven track record as first author in high-impact journals or manuscripts under revision; capable of conducting independent research with strong scientific enthusiasm and rigor.
d. Strong responsibility, excellent teamwork and communication skills, and proficient in English communication and scientific writing.
Bioinformatics
Main Responsibilities
a. Lead independent research projects and collaborate with other team members.
b. Assist the PI in mentoring graduate students and preparing grant proposals and manuscripts.
Qualifications
a. Ph.D. in bioinformatics, computational biology, systems biology, or a related field (obtained within the past three years or expected soon); experience in epigenomic data analysis (e.g., ChIP-Seq, ATAC-Seq, RNA-Seq), single-cell sequencing, or development of bioinformatics pipelines/algorithms is highly preferred.
b. Proficient in Python, R, and Linux; capable of processing and analyzing large-scale biological datasets.
c. Highly responsible, self-motivated, with excellent communication skills and a collaborative mindset.
d. Proficient in English communication and scientific writing.
Research Assistant
Main Responsibilities
a. Support research projects independently or in collaboration with lab members.
b. Assist with daily lab operations, including the management of supplies and ordering of reagents.
Qualifications
a. Bachelor’s degree or above in immunology, oncology, molecular and cellular biology, or related fields.
b. Prior research experience in molecular biology and cell culture is preferred.
c. Self-motivated researcher with strong sense of responsibility, good communication skills, and teamwork ability.
d. Basic proficiency in English communication and scientific writing.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please send resume and related application materials to and indicate the applicant name and specific job position in the email subject. Please combine your CV, one-page personal statement, contact information of no less than two referees and a 1-2 page research summary and interests (for postdoc applicant only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to zhangyu@cimrbj.ac.cn, and indicate “Research Scientists/Postdoc/Research Assistant + Your Name” in the email subject. Application review will begin on a rolling basis and qualified applicants will be invited for interview.
Contact person: Dr. Zhang
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來源于網絡，如有變更請以原發布者為準。
來源鏈接：
https://mp.weixin.qq.com/s/3ZM3FBkKU6lccdpPFwds-A
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