一、中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
二、實驗室介紹
周欣研究員先后在吉林大學、中國科學院分子細胞科學卓越創新中心（生物化學與細胞生物學研究所）獲得學士
嵌合抗原受體細胞免疫療法（CAR-T）是一種工程化人體免疫細胞來殺傷腫瘤的新型免疫治療療法，在白血病、淋巴瘤、多發性骨髓瘤中取得了備受矚目的療效，目前全球已有多款商業化產品，但在實體腫瘤中療效還有諸多挑戰。周欣研究員長期專注于開發和優化新型CAR-T細胞免疫療法，探索提高CAR-T免疫療法在實體瘤中療效的細胞工程策略。實驗室的研究以滿足CAR-T在實體瘤中轉化應用的迫切臨床需求為導向，圍繞CAR免疫療法在實體瘤治療中的挑戰，將開展基礎和轉化研究。
掃碼查看詳情_二維碼（請點擊鏈接查看詳情）
三、實驗室研究方向
實驗室將綜合利用分子生物學、細胞生物學、流式細胞術、小鼠腫瘤模型、高通量測序等技術和手段，開展（不限）以下課題研究：
l 開發新型靶向實體腫瘤（如胰腺癌）的CAR-NKT細胞療法；
l 探索現有兩種不同CAR-T產品（以CD28和以41BB為共刺激分子）細胞通路機制，以期開發下一代CAR-T產品；
l 高通量測序篩選理解腫瘤細胞耐受CAR-T療法的機制，以期指導靶向聯合治療手段。
四、主要成果與貢獻
1.成功構建小鼠CAR-NKT細胞平臺，并證明其可以通過調控腫瘤微環境，在多種實體腫瘤中展現出更強的抗腫瘤效果（Nature Cancer, 2024）。
2.通過修改優化CAR分子結構來增強CAR-T治療的療效（Journal for Immunotherapy of
Cancer, 2021; Nature Cancer, 2021; Cellular & Molecular Immunology, 2024）（專利，2021, WO
3.探索調控巨噬細胞中炎癥產生的新的分子機制以及在炎癥相關疾病中的作用的功能（Cell Reports, 2019, 2020; The Journal of Clinical Investigation, 2015）。
五、代表性文章
Nature Cancer, 2024 Nov; 5(11): 1607-1621.PMID: 39354225.
Cellular & Molecular Immunology, 2024 Aug; 21(8): 905-917.PMID: 38937625.
Journal for Immunotherapy of Cancer, 2021 Apr; 9(4): e002173.PMID: 33795386.
Cell Reports.2019 Apr 23; 27(4): 1176-1189.e5.PMID: 31018132.
六、崗位信息
01助理研究員
1）主要職責
1.在PI指導下獨立開展研究工作；
2.協助指導研究生工作以及撰寫論文或基金申請；
3.協助PI管理實驗室。
2）任職要求
1.以第一作者身份在領域內主流期刊上發表過研究論文；
2.有小鼠腫瘤模型，免疫治療，AAV基因治療等實驗背景者優先考慮；
3.具備獨立開展科研工作和指導研究生能力，有實驗室管理經驗優先考慮；
4.具備流利的英語讀寫和日常交流能力，能夠使用英文撰寫論文。
02博士后
1）主要職責
1.在PI指導下獨立開展研究工作；
2.協助指導研究生工作以及撰寫論文或基金申請。
2）任職要求
1.具有生命科學或其他相關生物醫學領域的研究背景，即將獲得博士學位或已獲得博士學位（原則上不超過3年）；
2.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文，能夠獨立開展研究工作；
3.具備獨立開展科研工作和指導研究生能力，具有科研熱情和嚴謹的科研態度；
4.熟練掌握分子生物學、免疫細胞培養、動物實驗基本操作和原理；
5.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。
七、福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
八、申請方法
應聘者請將個人簡歷、研究興趣或計劃，以及2-3名推薦人（僅限博士后應聘）的姓名及聯系方式，以及其他能證明科研能力的相關電子文件發送到郵箱zhouxin@cimrbj.ac.cn，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】，郵件主題請注明“應聘者名字+具體應聘職位”。
聯系人：
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
另外本實驗室歡迎有對細胞免疫療法感興趣的各階段實習生、聯培生前來學習交流。
ABOUT CIMR
The Chinese Institutes
for Medical Research (CIMR) is a newly founded institution dedicated to
fundamental and translational medical research.The CIMR is located at the main
campus of the
Laboratory Introduction
Chimeric antigen receptor cell immunotherapy (CAR-T) is a new type of immunotherapy that engineers’ human immune cells to kill tumors.It has achieved remarkable results in leukemia, lymphoma, and multiple myeloma, and there are currently many commercial products worldwide.However, significant challenges remain in enhancing its efficacy against solid tumors.The Zhou Laboratory at CIMR is dedicated to developing and optimizing next-generation CAR-T cell therapies, with a particular focus on innovative cell engineering strategies to improve their effectiveness in solid tumors.
Lab website：
QR code（請點擊鏈接查看詳情）
Major Research Projects
The laboratory will comprehensively utilize molecular biology, cell biology, flow cytometry, mouse tumor models, high-throughput sequencing, and other technologies and methods to research the following topics (not limited):
a.Explore the potential of CAR-NKT cell therapy in pancreatic cancer and other solid tumors.
b.Develop and refine new strategies to enhance CAR-T cell persistence, improving the effectiveness of CAR-T therapy in solid tumors.
c.High-throughput sequencing screening to understand the mechanism of tumor cell tolerance to CAR-T therapy, to guide targeted combined treatment methods.
Major Contributions
a.Generating the murine CAR NKT platform and demonstrating their superior anti-tumor effect in multiple solid tumors via programming the tumor microenvironment (Nature Cancer, 2024).
b.Enhancing the
efficacy of CAR-T treatment by modifying CAR structure (Journal for
Immunotherapy of Cancer, 2021; Nature Cancer, 2021; Cellular & Molecular
Immunology, 2024) (Patent, 2021, WO
c.Identifying the new mechanism to regulate inflammation and macrophage polarization (Cell Reports, 2019, 2020; The Journal of Clinical Investigation, 2015).
Representative Publications
Nature Cancer, 2024 Nov; 5(11): 1607-1621.PMID: 39354225.
Cellular & Molecular Immunology, 2024 Aug; 21(8): 905-917.PMID: 38937625.
Journal for Immunotherapy of Cancer, 2021 Apr; 9(4): e002173.PMID: 33795386.
Cell Reports.2019 Apr 23; 27(4): 1176-1189.e5.PMID: 31018132.
Open Positions
Research Assistant Investigator
Main Responsibilities
a.Ability to independently conduct scientific research and guide graduate students, experience in laboratory management is preferred
b.Getting involved in lab data analysis and management.
c.Assist in guiding other lab members and writing papers or funding applications.
Qualifications
a.Published or about to publish research papers as the first author in reputable journals in the field.
b.Research experience in mouse tumor models, immunotherapy, AAV gene therapy etc.are preferred.
c.Self-motivated researcher with good communication skills and teamwork ability.
d.Proficient in English reading, writing, and daily communication.
Postdoctoral Researcher
Main Responsibilities
a.Conducting research projects independently.
b.Assisting PI to mentor graduate students, and write grant proposals and manuscripts.
Qualifications
a.Backgrounds in biology or biomedical fields.Either about obtaining a Ph.D.or recently obtaining a Ph.D.degree (ideally within the last 3 years).
b.Published or about to publish research papers as the first author in reputable journals in the field.
c.Have the ability to independently carry out scientific research and guide graduate students and have scientific research enthusiasm and rigorous scientific research attitude.
d.Strong research experience in molecular biology, immune cell culture, FACS, and mice experiments.
e.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.
Welfare Treatment
a.Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b.Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c.Opportunities for career development and available professional guidance.
How to apply
To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhouxin@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.
Contact Person: Xin Zhou
This recruitment is valid for the long term until a suitable candidate is recruited.
Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.
信息來源于網絡，如有變更請以原發布者為準。
來源鏈接：
https://mp.weixin.qq.com/s/WqffOH7gNRlMAS8uMYLdnQ
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